Endocrine Abstracts

Background: Hip fractures are associated with high morbidity and mortality rates amongst older adults. The Irish Hip Fracture Database Standard 5 requires that all patients with a hip fracture have a bone health assessment completed. The majority are prescribed bone protection therapy to reduce further fractures. We sought to analyse the compliance and receipt of bone protection in patients presenting for DXA scan post hip fracture.Methods: We retrospect...

Introduction: Cataract development as a complication of diabetes is usually associated with increased age and longer duration of diabetes. However, rapidly progressive cataracts have also been described at, or soon after, diagnosis of type 1 diabetes (T1DM). We report two cases of adolescents with T1DM and bilateral cataracts, including one case in which visual loss was the presenting symptom.Cases: A 16-year old non-obese, caucasian boy presented to his...

Introduction: UK Screening for CHT was introduced in 1981 to facilitate early detection, treatment and prevent associated morbidity and mortality. Screening in the North East and Cumbria is coordinated by the XXXXXX. A locally defined threshold of TSH >6 mU/l constitutes a positive screening test in contrast to national guidance of > 10 mU/l. We explored the longer-term outcomes of infants identified by the screening programme.Aim: The aims of th...

It is known that a subset of obese individuals do not exhibit features of the metabolic syndrome (Met-S); these are referred to as being metabolically healthy obese (MHO) individuals. Conversely there are other individuals who although have a normal BMI are insulin resistant and exhibit some of the features of the Met-S and are termed as being metabolically unhealthy normal weight (MUHNW) individuals. This study aims to identify the prevalence of metabolic health among a diffe...

Background: Raised blood pressure (BP) in adolescents with type 1 Diabetes Mellitus (T1DM) has been associated with adverse cardiovascular outcomes independently of raised HbA1c. It is therefore of critical importance that these patients are identified early and appropriate treatment instigated. Of concerns, studies have recognised suboptimal management of hypertension in most of these young people, allowing them to succumb to complications of diabetes with hypertension in the...

Introduction: There has been much interest recently in measuring both salivary cortisol and cortisone due to the presence of 11β-hydroxysteroid dehydrogenase type 2 enzyme in the salivary glands. This enzyme facilitates the conversion of cortisol to cortisone; hence the concentration of cortisone in saliva may also be of interest. Studies have shown recently that salivary cortisone and cortisol are good markers of serum free cortisol status.Methods:...

We present the case of a 62 year old gentleman who was diagnosed with Acromegaly in 1998.He commenced testosterone replacement therapy in the form of Sustanon every three weeks in October 2000 following a testosterone level of 6.6 nmol/l.PSA levels during treatment with Sustanon were: 01/03/01–5.1μg/l.06/04/01–4.9 μg/l at which point he was referred for a urological opinion.<p class="a...

Background: Testosterone replacement therapy is available in a variety of preparations. Nebido, a long acting testosterone undecanoate injection offered at 3 monthly intervals, has recently become available thus reducing the need for frequent injections.Aim: To investigate the efficacy and safety of Nebido.Patients and methods: Eighteen patients aged between 22–77 years (median 44.5 years) with primary or secondary hypogonadis...

Case History: A 16 yr old patient presented to us concerned about her short statue. Her father and mother were at the 9th centile and her sister was at the 25th centile in adult life. She was otherwise well having gone through a normal puberty in her early teens and was currently on the oral contraceptive pill having regular periods. On examination she did display some features of Turner’s syndrome; short stature, short neck and cubitus valgus deformity. Cytogenetic analy...

Objective: Our aim was to identify and treat sleep disorders in asymptomatic patients with craniopharyngioma and to identify co-existing respiratory disease.Methods: 5 patients (1 male) with a diagnosis of craniopharyngioma, were identified from the local pituitary database and admitted for polysomnography (Alice 4, Respironics), as part of a study of hypothalamic disease in craniopharyngioma. Sleep disturbance was defined as an apnoea index (AHI) of &#6...